Disintegration test is done at this temperature:

Disintegration test is done at this temperature:

• A. 35 to 39 °C
• B. 36.5 to 37.5 °C
• C. 36 to 37 °C
• D. 37 °C

Answer: (A)

Disintegration testing uses a bath temperature that mirrors human body temperature to ensure the dosage form hydrates and breaks apart as it would in the GI tract. The standard tolerance is 37°C with an allowable range of ±2°C, which gives 35 to 39°C. This wider range accounts for minor lab variations while keeping results comparable across tests. So the test is performed at 35–39°C. While 37°C is the target, the official specification uses the broader range to reflect practical conditions in different laboratories. The other options are either too narrow or not aligned with the standard tolerance used in pharmacopeial disintegration testing.

Disintegration testing uses a bath temperature that mirrors human body temperature to ensure the dosage form hydrates and breaks apart as it would in the GI tract. The standard tolerance is 37°C with an allowable range of ±2°C, which gives 35 to 39°C. This wider range accounts for minor lab variations while keeping results comparable across tests. So the test is performed at 35–39°C. While 37°C is the target, the official specification uses the broader range to reflect practical conditions in different laboratories. The other options are either too narrow or not aligned with the standard tolerance used in pharmacopeial disintegration testing.